2986486-82-0
Chemical Structure
HDAC6-IN-37
- CAS No.: 2986486-82-0
- Formula:C19H16ClN3O2S
- Molecular Weight:385.87
InChIKey: PCGYBRQMPFDGRF-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(C=C1)CN2C3=CC=CC=C3SC4=C2C=CC=C4)NO.Cl
Biological Activity: HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue[1].
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HDAC6-IN-37 | HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue. | |||||||||||||||||||||
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