2986564-20-7
Chemical Structure
HSP90-IN-11
- CAS No.: 2986564-20-7
- Formula:C27H30FN3O6
- Molecular Weight:511.54
IUPAC Name: 4-(3-hydroxyphenyl)-8-methoxy-2-thioxo-1,2,3,4-tetrahydrobenzo[h]quinazoline-5,6-dione
InChIKey: IXBOVNPTMCWXOD-UHFFFAOYSA-N
SMILES: CCN(C1=CC=C(C=C1)CN2C(C(F)=CN(C2=O)C3CCCO3)=O)C(C4=CC(C(C)C)=C(C=C4O)O)=O
Biological Activity: HSP90-IN-11 is a HSP90 inhibitor with an IC50 of 27.8 nM. HSP90-IN-11 inhibits the activity of HSP90, which in turn induces rapid degradation of EGFR and Akt proteins in non-small cell lung cancer (NSCLC) cells. HSP90-IN-11 induces accumulation of the G1 subphase cell population in NSCLC cells, activates caspase-3, caspase-8, caspase-9 and PARP, thereby triggering apoptosis. HSP90-IN-11 exhibits antiproliferative activity in colorectal cancer and NSCLC cells. HSP90-IN-11 can be used for the research of colorectal cancer and non-small cell lung cancer[1].
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HSP90-IN-11 | HSP90-IN-11 is a HSP90 inhibitor with an IC50 of 27.8 nM. HSP90-IN-11 inhibits the activity of HSP90, which in turn induces rapid degradation of EGFR and Akt proteins in non-small cell lung cancer (NSCLC) cells. HSP90-IN-11 induces accumulation of the G1 subphase cell population in NSCLC cells, activates caspase-3, caspase-8, caspase-9 and PARP, thereby triggering apoptosis. HSP90-IN-11 exhibits antiproliferative activity in colorectal cancer and NSCLC cells. HSP90-IN-11 can be used for the research of colorectal cancer and non-small cell lung cancer. | |||||||||||||||||||||
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