2987586-62-7
Chemical Structure
Topoisomerase II inhibitor 6
- CAS No.: 2987586-62-7
- Formula:C19H18N4O2
- Molecular Weight:334.37
IUPAC Name: 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione
InChIKey: HOWBMJAMTGIXDS-UHFFFAOYSA-N
SMILES: O=C1C2=NC3=C(C(N2C4=C1C(NCCN(C)C)=CC=C4)=O)C=CC=C3
Biological Activity: Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases[1].
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Topoisomerase II inhibitor 6 | Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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