2988012-71-9
Chemical Structure
Pegevongitide
Synonym(s): AV-001
- CAS No.: 2988012-71-9
- Formula:N/A
- Molecular Weight:14600 (Approximately)
SMILES: O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CO)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CNC=N5)NC(CCSCC(NCCOCCC(CCOCCNC(CSCCC(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CC8=CNC=N8)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](CO)C(N[C@@H](CC%10=CC=CC=C%10)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)(CCOCCNC(CSCCC(N[C@@H](CC%11=CNC=N%11)C(N[C@@H](CC%12=CNC=N%12)C(N[C@@H](CC%13=CNC=N%13)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%14=CNC=N%14)C(N[C@@H](CO)C(N[C@@H](CC%15=CC=CC=C%15)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCOCCNC(CSCCC(N[C@@H](CC%16=CNC=N%16)C(N[C@@H](CC%17=CNC=N%17)C(N[C@@H](CC%18=CNC=N%18)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%19=CNC=N%19)C(N[C@@H](CO)C(N[C@@H](CC%20=CC=CC=C%20)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.[n]
Biological Activity: Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pegevongitide | 99.60% | Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia. | ||||||||||||||||||||
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References
- [1]. H. Kim, et al. Synthetic Tie2 Agonist AV-001 Protects Against Endothelial Cell Permeability Induced by SARS-CoV-2 Infection/COVID-19, American Journal of Respiratory and Critical Care Medicine, Volume 211, Issue Supplement_1, May 2025, Page A7874.
- [2]. Gao H, et al. Early therapeutic effects of an Angiopoietin-1 mimetic peptide in middle-aged rats with vascular dementia. Frontiers in aging neuroscience. 2023;15:1180913. [Content Brief]
