2989904-86-9
2989904-86-9
Chemical Structure
EGFR-IN-204
- CAS No.: 2989904-86-9
- Formula:C31H28FN7O3
- Molecular Weight:565.60
InChIKey: WEOIUNUHGPJUAV-NPHXMPSESA-N
SMILES: FC(C(C)=C(C=C1)OC2=CC3=NC=NN3C=C2)=C1NC4=NC=NC(C=C5)=C4C=C5O[C@@H]6C[C@H](CC7)N(C(C=C)=O)[C@H]7C6
Biological Activity: EGFR-IN-204 (Example 1) is a HER2 exon 20 mutation inhibitor with selectivity for wild-type EGFR. EGFR-IN-204 exerts antiproliferative effects on cells dependent on HER2 exon 20 YVMA insertion mutation and wild-type HER2, and shows strong selectivity over cells dependent on wild-type EGFR. EGFR-IN-204 is applicable to non-small cell lung cancer research[1].
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EGFR-IN-204 | 98.57% | EGFR-IN-204 (Example 1) is a HER2 exon 20 mutation inhibitor with selectivity for wild-type EGFR. EGFR-IN-204 exerts antiproliferative effects on cells dependent on HER2 exon 20 YVMA insertion mutation and wild-type HER2, and shows strong selectivity over cells dependent on wild-type EGFR. EGFR-IN-204 is applicable to non-small cell lung cancer research. | ||||||||||||||||||||
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