2989973-69-3
Chemical Structure
Biotin-V
- CAS No.: 2989973-69-3
- Formula:C30H36BrN7OS2
- Molecular Weight:654.69
InChIKey: MJVONGYPKJWSEU-ITYLBNPASA-N
SMILES: CN(C)C(C=C1)=CC=C1/C=C/C2=[N+](C3=CC=CC=C3S2)CC4=CN(N=N4)CCCCC[C@@H]5[C@@]6([H])[C@@](NC(N6)=O)([H])CS5.[Br-]
Biological Activity: Biotin-V is a fluorescent probe targeting the biotin receptor (BiR), which can be used to detect changes in intracellular viscosity in cancer cells and tumor tissues. Biotin-V consists of a viscosity-responsive TICT (twisted internal charge transfer) fluorophore and a biotin-targeting moiety. In a high-viscosity environment, intramolecular rotation is restricted, which reduces non-radiative transitions and enhances fluorescence intensity and fluorescence lifetime. Biotin-V enters BiR-positive cancer cells via biotin receptor-mediated uptake, and mainly localizes to mitochondria, enabling dual-modal viscosity imaging (fluorescence intensity imaging and fluorescence lifetime imaging) (Ex/Em = 540/608 nm; cell imaging Ex/Em = 561/570-620 nm)[1].
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Biotin-V | Biotin-V is a fluorescent probe targeting the biotin receptor (BiR), which can be used to detect changes in intracellular viscosity in cancer cells and tumor tissues. Biotin-V consists of a viscosity-responsive TICT (twisted internal charge transfer) fluorophore and a biotin-targeting moiety. In a high-viscosity environment, intramolecular rotation is restricted, which reduces non-radiative transitions and enhances fluorescence intensity and fluorescence lifetime. Biotin-V enters BiR-positive cancer cells via biotin receptor-mediated uptake, and mainly localizes to mitochondria, enabling dual-modal viscosity imaging (fluorescence intensity imaging and fluorescence lifetime imaging) (Ex/Em = 540/608 nm; cell imaging Ex/Em = 561/570-620 nm). | |||||||||||||||||||||
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