2990065-87-5
Chemical Structure
ADH-6 TFA
- CAS No.: 2990065-87-5
- Formula:C31H37F3N8O11
- Molecular Weight:754.67
IUPAC Name: methyl 6-(3-aminopropoxy)-5-(6-(3-aminopropoxy)-5-(6-butoxy-5-nitropicolinamido)picolinamido)picolinate 2,2,2-trifluoroacetate
InChIKey: GFIRNLARNWCPHE-UHFFFAOYSA-N
SMILES: O=C(C1=NC(OCCCN)=C(NC(C2=NC(OCCCN)=C(NC(C3=NC(OCCCC)=C([N+]([O-])=O)C=C3)=O)C=C2)=O)C=C1)OC.OC(C(F)(F)F)=O
Biological Activity: ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases[1].
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ADH-6 TFA | 99.67% | ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases. | ||||||||||||||||||||
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