2991434-57-0
2991434-57-0
Chemical Structure
Setomagpran
- CAS No.: 2991434-57-0
- Formula:C22H19Cl2F6N5O
- Molecular Weight:554.32
InChIKey: DBDJWFSUEOBYFN-QWHCGFSZSA-N
SMILES: FC(F)(F)C1=NC(C=CC(Cl)=C2)=C2C(N[C@@H]3C[C@@H](CCC3)NC(C4=CN(N=C4Cl)CC(F)(F)F)=O)=C1
Biological Activity: Setomagpran is an antagonist of Mas-related G protein-coupled receptor X2 (MRGPRX2). Setomagpran inhibits MRGPRX2-mediated Gαq protein recruitment signaling, exhibiting an inhibitory IC50 of 236 nM in HEK293T cells transiently expressing MRGPRX2. Setomagpran can be used in research on MRGPR-mediated diseases, such as inflammatory disorders[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Setomagpran | Setomagpran is an antagonist of Mas-related G protein-coupled receptor X2 (MRGPRX2). Setomagpran inhibits MRGPRX2-mediated Gαq protein recruitment signaling, exhibiting an inhibitory IC50 of 236 nM in HEK293T cells transiently expressing MRGPRX2. Setomagpran can be used in research on MRGPR-mediated diseases, such as inflammatory disorders. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
