299173-64-1
299173-64-1
Chemical Structure
17-Demethoxy-reblastatin
Synonym(s): 17-DR
- CAS No.: 299173-64-1
- Formula:C28H42N2O7
- Molecular Weight:518.64
InChIKey: HUXWGTSMSXMDBH-UQMARRQJSA-N
SMILES: C[C@@H](/C=C1C)[C@@H](O)[C@@H](OC)C[C@H](C)CC2=CC(O)=CC(NC(/C(C)=C/CC[C@H](OC)[C@H]\1OC(N)=O)=O)=C2
Biological Activity: 17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90), with an IC50 of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway[1].
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17-Demethoxy-reblastatin | 17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90), with an IC50 of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway. | |||||||||||||||||||||
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