2994198-37-5
2994198-37-5
Chemical Structure
Heme Oxygenase-2-IN-1
- CAS No.: 2994198-37-5
- Formula:C19H17N3O2
- Molecular Weight:319.36
IUPAC Name: 4-((4-(1-hydroxy-2-(1H-imidazol-1-yl)ethyl)phenoxy)methyl)benzonitrile
InChIKey: IAXRZMXWRYOKKF-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(COC2=CC=C(C(O)CN3C=CN=C3)C=C2)C=C1
Biological Activity: Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC50 values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Heme Oxygenase-2-IN-1 | 98.82% | Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC50 values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively. | ||||||||||||||||||||
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SKF-96365 (hydrochloride) | 99.93% | SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice. SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia. | ||||||||||||||||||||
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Denzimol | Denzimol is an orally active anticonvulsant agent. Denzimol inhibits cytochrome P450, and interacts with benzodiazepine receptors. Denzimol selectively antagonizes tonic components of Metrazol-induced seizures in rats and mice. Denzimol can be used for the research of epilepsy and convulsions. | |||||||||||||||||||||
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Denzimol hydrochloride | Denzimol hydrochloride is an orally active anticonvulsant agent. Denzimol hydrochloride inhibits cytochrome P450, and interacts with benzodiazepine receptors. Denzimol hydrochloride selectively antagonizes tonic components of Metrazol-induced seizures in rats and mice. Denzimol hydrochloride can be used for the research of epilepsy and convulsions. | |||||||||||||||||||||
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Dazoxiben | Dazoxiben is a potent and orally active thromboxane synthetase inhibitor. Dazoxiben has the potential for the research of Raynaud's syndrome. | |||||||||||||||||||||
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SKF-96365 | 99.97% | SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice. SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia. | ||||||||||||||||||||
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Nafimidone alcohol | Nafimidone alcohol is the major metabolic of Nafimidone in plasma and urine. Nafimidone alcohol is promising for research of onset seizures. | |||||||||||||||||||||
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O4I1 | 98.05% | O4I1 is an Oct3/4 modulator with activity toward induced-pluripotent stem cell generation.O4I1 enhances Oct3/4 expression, increases Oct3/4 protein levels, and promotes Oct3/4-mediated transcriptional activity.O4I1 can be used for the research of regenerative medicine. | ||||||||||||||||||||
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Oct3/4-inducer-1 | 98.12% | Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer. Oct3/4-inducer-1 promotes expression and stabilization of Oct3/4, and enhances its transcriptional activity in diverse human somatic cells. | ||||||||||||||||||||
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Econazole | 99.93% | Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage. | ||||||||||||||||||||
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1,4-Bis(pyridin-4-ylmethoxy)benzene | 1,4-Bis(pyridin-4-ylmethoxy)benzene is a metal-organic framework (MOF). | |||||||||||||||||||||
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