30021-77-3
Chemical Structure
Cleistanthin B
Synonym(s): Diphyllin O-glucoside
- CAS No.: 30021-77-3
- Formula:C27H26O12
- Molecular Weight:542.49
IUPAC Name: 9-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphtho[2,3-c]furan-1(3H)-one
InChIKey: BJGIWVGXMRUMNA-WBYCZGBQSA-N
SMILES: O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)=C2CO1
Biological Activity: Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].
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Cleistanthin B | Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo. | |||||||||||||||||||||
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References
- [1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471. [Content Brief]
- [2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388. [Content Brief]
- [3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7. [Content Brief]
- [4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14. [Content Brief]
