300399-36-4
Chemical Structure
HDAC1 activator-1
- CAS No.: 300399-36-4
- Formula:C17H24O4
- Molecular Weight:292.37
InChIKey: FUBBMUWBTVRWRE-UHFFFAOYSA-N
SMILES: O=C1C(CC2C(CC(C)(CC2=O)C)=O)=C(CC(C)(C1)C)O
Biological Activity: HDAC1 activator-1 is a specific HDAC1 activator with orally activity, exerting no significant effects on other HDAC family members. HDAC1 activator-1 exhibits neuroprotective activity, ameliorates cognitive and motor function deficits by reducing neuronal loss and gliosis. HDAC1 activator-1 specifically activates HDAC1 in SH-SY5Y cells and exerts regulatory effects on aberrant cell cycle and DNA damage. HDAC1 activator-1 can be used for the research of TDP-43 proteinopat1-related neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and cerebral ischemia-related neurological injury[1][2].
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HDAC1 activator-1 | HDAC1 activator-1 is a specific HDAC1 activator with orally activity, exerting no significant effects on other HDAC family members. HDAC1 activator-1 exhibits neuroprotective activity, ameliorates cognitive and motor function deficits by reducing neuronal loss and gliosis. HDAC1 activator-1 specifically activates HDAC1 in SH-SY5Y cells and exerts regulatory effects on aberrant cell cycle and DNA damage. HDAC1 activator-1 can be used for the research of TDP-43 proteinopat1-related neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and cerebral ischemia-related neurological injury. | |||||||||||||||||||||
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References
- [1]. Wu CC, et al. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies. EMBO Mol Med. 2020 Jun 8;12(6): e10622
- [2]. Giuliana Costanzo, et al. Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders. European Journal of Medicinal Chemistry. 2025, 298, 117998.
