3005979-40-5
3005979-40-5
Chemical Structure
AR antagonist 11
- CAS No.: 3005979-40-5
- Formula:C20H17ClN2O
- Molecular Weight:336.81
SMILES: ClC(C=C1)=CC=C1[C@@H]([C@@H]2[C@H]3OCC2)NC4=C3C5=CC=CN=C5C=C4
Biological Activity: AR antagonist 11 (Compound c2) is a selective AR antagonist with an IC50 of 0.019 μM. AR antagonist 11 is also effective against ARF877L/T878A mutant (IC50: 1.03 μM). AR antagonist 11 inhibits LNCaP cell proliferation and reduces PSA protein expression (IC50: 0.54 μM). AR antagonist 11 can be used for research of prostate cancer (PCa)[1].
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AR antagonist 11 | AR antagonist 11 (Compound c2) is a selective AR antagonist with an IC50 of 0.019 μM. AR antagonist 11 is also effective against ARF877L/T878A mutant (IC50: 1.03 μM). AR antagonist 11 inhibits LNCaP cell proliferation and reduces PSA protein expression (IC50: 0.54 μM). AR antagonist 11 can be used for research of prostate cancer (PCa). | |||||||||||||||||||||
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