3006905-22-9
3006905-22-9
Chemical Structure
PI3K/HDAC-IN-3
- CAS No.: 3006905-22-9
- Formula:C34H34F2N6O5S
- Molecular Weight:676.73
InChIKey: KSQGUTYIJILXDH-UHFFFAOYSA-N
SMILES: CC1=C2C(C(OCCCCCCC(NC3=C(C=CC=C3)N)=O)=CC(C4=CC(NS(C5=CC=C(F)C=C5F)(=O)=O)=C(OC)N=C4)=C2)=NC=N1
Biological Activity: PI3K/HDAC-IN-3 (36) is a PI3K and HDAC dual inhibitor, with IC50 values of 0.23 nM and 172 nM for PI3Kα and HDAC1, respectively. PI3K/HDAC-IN-3 (36) suppresses AKT phosphorylation and increased H3 acetylation in MV4-11 cells. PI3K/HDAC-IN-3 (36) exhibits significant and dose-dependent anticancer efficacy in a MV4-11 xenograft model[1].
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PI3K/HDAC-IN-3 | PI3K/HDAC-IN-3 (36) is a PI3K and HDAC dual inhibitor, with IC50 values of 0.23 nM and 172 nM for PI3Kα and HDAC1, respectively. PI3K/HDAC-IN-3 (36) suppresses AKT phosphorylation and increased H3 acetylation in MV4-11 cells. PI3K/HDAC-IN-3 (36) exhibits significant and dose-dependent anticancer efficacy in a MV4-11 xenograft model. | |||||||||||||||||||||
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