3007565-26-3
3007565-26-3
Chemical Structure
PI3Kα/HDAC6-IN-1
- CAS No.: 3007565-26-3
- Formula:C27H30F3N7O6S2
- Molecular Weight:669.70
InChIKey: PLBBMNVLYUEPKQ-MOPGFXCFSA-N
SMILES: CC(C(F)(F)F)(C)C1=CC(C2=C(C)N=C(NC(N3C[C@H](NS(=O)(CC4=CC=C(C(NO)=O)C=C4)=O)C[C@H]3C(N)=O)=O)S2)=CC=N1
Biological Activity: PI3Kα/HDAC6-IN-1 (compound 21j) is a dual PI3Kα/HDAC6 inhibitor with IC50 of 2.9 and 26 nM, respectively. PI3Kα/HDAC6-IN-1 also inhibits AKT(Ser473) phosphorylation and induces the accumulation of acetylated α-tubulin without affecting acetylated histones H3 and H4. PI3Kα/HDAC6-IN-1 efficiently inhibits L-363 cell line (IC50=0.17 μM) and has good anti-cancer activity[1].
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PI3Kα/HDAC6-IN-1 | PI3Kα/HDAC6-IN-1 (compound 21j) is a dual PI3Kα/HDAC6 inhibitor with IC50 of 2.9 and 26 nM, respectively. PI3Kα/HDAC6-IN-1 also inhibits AKT(Ser473) phosphorylation and induces the accumulation of acetylated α-tubulin without affecting acetylated histones H3 and H4. PI3Kα/HDAC6-IN-1 efficiently inhibits L-363 cell line (IC50=0.17 μM) and has good anti-cancer activity. | |||||||||||||||||||||
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