3010256-54-6
3010256-54-6
Chemical Structure
VEGFR/PARP-IN-1
- CAS No.: 3010256-54-6
- Formula:C29H27N9O
- Molecular Weight:517.58
InChIKey: DCYHJVFMNYSPNT-UHFFFAOYSA-N
SMILES: NC(C1=CC=CC2=C1N=C(N2)C3=C(C=CC(NC4=NC=CC(N(C)C5=CC6=NN(C(C)=C6C=C5)C)=N4)=C3)C)=O
Biological Activity: VEGFR/PARP-IN-1 (Compound 14b) is a VEGFR/PARP dual inhibitor (IC50s: 191 nM and 60.9 nM respectively). VEGFR/PARP-IN-1 inhibits DNA damage repair, induces cell apoptosis, and arrests cell in the G2/M phase. VEGFR/PARP-IN-1 has good antiproliferative efficacy against BRCA wild-type breast cancer cells (IC50: 4.1 and 3.5 μM for MDA-MB-231 and MCF-7 cells). VEGFR/PARP-IN-1 is an antitumor and anti-metastasis agent[1].
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VEGFR/PARP-IN-1 | VEGFR/PARP-IN-1 (Compound 14b) is a VEGFR/PARP dual inhibitor (IC50s: 191 nM and 60.9 nM respectively). VEGFR/PARP-IN-1 inhibits DNA damage repair, induces cell apoptosis, and arrests cell in the G2/M phase. VEGFR/PARP-IN-1 has good antiproliferative efficacy against BRCA wild-type breast cancer cells (IC50: 4.1 and 3.5 μM for MDA-MB-231 and MCF-7 cells). VEGFR/PARP-IN-1 is an antitumor and anti-metastasis agent. | |||||||||||||||||||||
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