301177-36-6
301177-36-6
Chemical Structure
RH01386
- CAS No.: 301177-36-6
- Formula:C18H15F3N4O3S
- Molecular Weight:424.40
IUPAC Name: 4-cyclohexyl-2-((2-nitro-4-(trifluoromethyl)phenyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
InChIKey: BVWCKDMNROTYMZ-UHFFFAOYSA-N
SMILES: N#CC1=C(C2CCCCC2)N=C(SC3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)NC1=O
Biological Activity: RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1].
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RH01386 | 98.66% | RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment. | ||||||||||||||||||||
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