3012597-48-4
Chemical Structure
Cy3-NO2-Tre
- CAS No.: 3012597-48-4
- Formula:C48H61BrN4O13
- Molecular Weight:981.92
InChIKey: WCJHPFGKEPUYBG-YHKDYSKUSA-N
SMILES: CC1(C)C2=CC=CC=C2[N+](CC3=CC=C(C=C3)[N+]([O-])=O)=C1/C=C/C=C4N(C5=CC=CC=C5C/4(C)C)CCCCCC(NC[C@H]6O[C@@H]([C@@H]([C@H]([C@@H]6O)O)O)O[C@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)=O.[Br-]
Biological Activity: Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb). Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm)[1].
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Cy3-NO2-Tre | Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb). Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm). | |||||||||||||||||||||
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