3012609-63-8
Chemical Structure
ATR-IN-20
- CAS No.: 3012609-63-8
- Formula:C29H31N5O4S
- Molecular Weight:545.65
IUPAC Name: (R)-(2-(1H-indol-4-yl)-7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)(3-(methylsulfonyl)phenyl)methanone
InChIKey: LKHMVKNMSWRHJH-GOSISDBHSA-N
SMILES: O=C(N1C(C)(C)C2=NC(C3=CC=CC4=C3C=CN4)=NC(N5[C@H](C)COCC5)=C2C1)C6=CC=CC(S(=O)(C)=O)=C6
Biological Activity: ATR-IN-20 is a potent ATR (ATM/ATR) inhibitor with an IC50 of 3 nM. ATR-IN-20 possess an inhibitory effect on mTOR (IC50 of 18 nM) while displaying good selectivity against PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM). ATR-IN-20 exhibits excellent pharmacokinetic profile (F = 30%), and has anticancer effects[1].
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ATR-IN-20 | ATR-IN-20 is a potent ATR (ATM/ATR) inhibitor with an IC50 of 3 nM. ATR-IN-20 possess an inhibitory effect on mTOR (IC50 of 18 nM) while displaying good selectivity against PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM). ATR-IN-20 exhibits excellent pharmacokinetic profile (F = 30%), and has anticancer effects. | |||||||||||||||||||||
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