3014384-72-3
3014384-72-3
Chemical Structure
GPX4-IN-21
- CAS No.: 3014384-72-3
- Formula:C23H16ClN5O3
- Molecular Weight:445.86
InChIKey: XQEHJEDWEFOHQP-UHFFFAOYSA-N
SMILES: ClC1=CC(N2N=NC(C3=CC(C(NC4=CC=C(OCC(N5)=O)C5=C4)=O)=CC=C3)=C2)=CC=C1
Biological Activity: GPX4-IN-21 (Compound 4d) is a selective glutathione peroxidase 4 (GPX4) inhibitor. GPX4-IN-21 can induce ferroptosis and downregulate the ferroptosis-related proteins SLC7A11, SLC11A2 and GPX4 levels. GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity. GPX4-IN-21 can be used for the research of cancer, such as melanoma[1].
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GPX4-IN-21 | GPX4-IN-21 (Compound 4d) is a selective glutathione peroxidase 4 (GPX4) inhibitor. GPX4-IN-21 can induce ferroptosis and downregulate the ferroptosis-related proteins SLC7A11, SLC11A2 and GPX4 levels. GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity. GPX4-IN-21 can be used for the research of cancer, such as melanoma. | |||||||||||||||||||||
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