3014840-61-7
Chemical Structure
IRBM-Z-2
- CAS No.: 3014840-61-7
- Formula:C22H18F3N7O2
- Molecular Weight:469.42
InChIKey: JJQASPUODGTFMB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C(F)(F)F)=C1)[N-]C2=C[N+](CC3=CC=C(C4=C(C)N=CN=C4C)C=N3)=NO2
Biological Activity: IRBM-Z-2 is a non-competitive, orally active Zika virus (ZIKV) NS2B-NS3 protease inhibitor, with IC50 values of 0.04 μM and 3.1 μM against the wild-type and I156T mutant strains, respectively. IRBM-Z-2 exhibits broad-spectrum anti-flavivirus potential, with IC50 values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-1 inhibits ZIKV replication and alleviates virus-induced cytopathic effects. IRBM-Z-1 can be used in studies related to ZIKV infection[1].
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IRBM-Z-2 | IRBM-Z-2 is a non-competitive, orally active Zika virus (ZIKV) NS2B-NS3 protease inhibitor, with IC50 values of 0.04 μM and 3.1 μM against the wild-type and I156T mutant strains, respectively. IRBM-Z-2 exhibits broad-spectrum anti-flavivirus potential, with IC50 values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-1 inhibits ZIKV replication and alleviates virus-induced cytopathic effects. IRBM-Z-1 can be used in studies related to ZIKV infection. | |||||||||||||||||||||
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