3019958-44-9
3019958-44-9
Chemical Structure
CB1R Allosteric modulator 5
- CAS No.: 3019958-44-9
- Formula:C18H14Cl2N2O2
- Molecular Weight:361.22
SMILES: O=C1C(NC2=CC=C(Cl)C=C2)=C(NCCC3=CC(Cl)=CC=C3)C1=O
Biological Activity: CB1R Allosteric modulator 5 (compound 3) is a selective, and blood-brain barrier (BBB) permeable Cannabinoid receptor type 1 allosteric modulator with a pIC50 of 6.89. CB1R Allosteric modulator 5 attenuates both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity[1].
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CB1R Allosteric modulator 5 | 98.35% | CB1R Allosteric modulator 5 (compound 3) is a selective, and blood-brain barrier (BBB) permeable Cannabinoid receptor type 1 allosteric modulator with a pIC50 of 6.89. CB1R Allosteric modulator 5 attenuates both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity. | ||||||||||||||||||||
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References
- [1]. Nguyen T, et al. Development of Squaramides as Allosteric Modulators of the CB1 Receptor: Synthesis, Computational Studies, Biological Characterization, and Effects against Cocaine-Induced Behavioral Sensitization and Reinstatement in Rats. J Med Chem. 2025 Apr 24;68(8):8694-8712. [Content Brief]
