3019972-01-8
3019972-01-8
Chemical Structure
NF-κB-IN-14
- CAS No.: 3019972-01-8
- Formula:C15H12Cl2N4
- Molecular Weight:319.19
InChIKey: KQHCRNDNPXTCQH-NSCUHMNNSA-N
SMILES: CC1=CC=C(/C=C/CN2C=NC3=C(Cl)N=C(Cl)N=C23)C=C1
Biological Activity: NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages (IC50: 6.4 μM). NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model[1].
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NF-κB-IN-14 | NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages (IC50: 6.4 μM). NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model. | |||||||||||||||||||||
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