3022330-81-7
3022330-81-7
Chemical Structure
Multi-target kinase-IN-10
- CAS No.: 3022330-81-7
- Formula:C17H13FN2O2
- Molecular Weight:296.30
InChIKey: KVFBLZWIXQMRRU-UHFFFAOYSA-N
SMILES: OC1=CC=CC=C1C2=NN=C(OCC3=CC=C(F)C=C3)C=C2
Biological Activity: Multi-target kinase-IN-10 (Compound 6l) is an orally active, blood-brain barrier-permeable, selective, reversible, and competitive MAO-B inhibitor with an IC50 of 0.0053 μM. Multi-target kinase-IN-10 competes with substrates for binding to the active site of MAO-B, chelates Cu2+ ions, inhibits Cu2+-induced ROS production, and reduces the release of NO, TNF-α, and IL-1β. Multi-target kinase-IN-10 ameliorates Parkinson's disease[1].
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Multi-target kinase-IN-10 | Multi-target kinase-IN-10 (Compound 6l) is an orally active, blood-brain barrier-permeable, selective, reversible, and competitive MAO-B inhibitor with an IC50 of 0.0053 μM. Multi-target kinase-IN-10 competes with substrates for binding to the active site of MAO-B, chelates Cu2+ ions, inhibits Cu2+-induced ROS production, and reduces the release of NO, TNF-α, and IL-1β. Multi-target kinase-IN-10 ameliorates Parkinson's disease. | |||||||||||||||||||||
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