3023189-40-1
Chemical Structure
(R)-SL18
- CAS No.: 3023189-40-1
- Formula:C26H21ClN6O5S2
- Molecular Weight:597.07
InChIKey: LWZLLHPZXXUHDA-QHCPKHFHSA-N
SMILES: CN1C2=CC=CC=C2C(C3=CC=CC=C3)=N[C@@H](NC(SCC(NC(NC4=CC(Cl)=CC=C4[N+]([O-])=O)=O)=O)=S)C1=O
Biological Activity: (R)-SL18 is an annexin A3 (ANXA3) degrader with a Kd value of 1.15 μM for human ANXA3. (R)-SL18 induces ANXA3 degradation via the ubiquitination pathway, shows poor degradation selectivity among annexin family proteins, and its moderate ANXA3 binding affinity correlates with off-target effects. (R)-SL18 inhibits the proliferation, migration, invasion and colony formation of cancer cells. (R)-SL18 can be used in the research of triple-negative breast cancer[1].
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(R)-SL18 | (R)-SL18 is an annexin A3 (ANXA3) degrader with a Kd value of 1.15 μM for human ANXA3. (R)-SL18 induces ANXA3 degradation via the ubiquitination pathway, shows poor degradation selectivity among annexin family proteins, and its moderate ANXA3 binding affinity correlates with off-target effects. (R)-SL18 inhibits the proliferation, migration, invasion and colony formation of cancer cells. (R)-SL18 can be used in the research of triple-negative breast cancer. | |||||||||||||||||||||
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