3024470-62-7
3024470-62-7
Chemical Structure
Nav1.8-IN-20
- CAS No.: 3024470-62-7
- Formula:C18H10Cl2F3N3O4
- Molecular Weight:460.19
InChIKey: YGSBSLYVKJVIQK-UHFFFAOYSA-N
SMILES: ClC1=C(Cl)C=C(OC2=CC=C(OC(F)(F)F)C=C2)C(C(NC3=C[N+]([O-])=CN=C3)=O)=C1
Biological Activity: Nav1.8-IN-20 (Compound I) is an orally active and potent voltage-gated sodium channel Nav1.8 inhibitor with an IC50 value of 14 nM. Nav1.8-IN-20 blocks the generation and conduction of action potentials in peripheral nociceptive neurons, exerting analgesic effects. Nav1.8-IN-20 is promising for research of various pain types such as acute pain, chronic pain, inflammatory pain, and neuropathic pain[1].
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Nav1.8-IN-20 | Nav1.8-IN-20 (Compound I) is an orally active and potent voltage-gated sodium channel Nav1.8 inhibitor with an IC50 value of 14 nM. Nav1.8-IN-20 blocks the generation and conduction of action potentials in peripheral nociceptive neurons, exerting analgesic effects. Nav1.8-IN-20 is promising for research of various pain types such as acute pain, chronic pain, inflammatory pain, and neuropathic pain. | |||||||||||||||||||||
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