3024591-38-3
3024591-38-3
Chemical Structure
LI-3948
- CAS No.: 3024591-38-3
- Formula:C19H16Cl2FN3O3
- Molecular Weight:424.25
InChIKey: QHGIMBGZGUTRQK-NTDHXHIGSA-N
SMILES: FC1=C(C(N)=O)C=CC(N2)=C1[C@]3(CC[C@H](OC4=NC=C(Cl)C=C4Cl)CC3)C2=O
Biological Activity: LI-3948 is a blood-brain barrier-penetrant IP6K1 inhibitor with an IC50 of 16 nM. LI-3948 reduces locomotor activity and grooming behavior in mice and induces hypothermia. LI-3948 is a moderate P-glycoprotein efflux substrate, with low clearance in rodents and high plasma protein binding. LI-3948 can be used for central nervous system-related research[1].
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LI-3948 | 99.85% | LI-3948 is a blood-brain barrier-penetrant IP6K1 inhibitor with an IC50 of 16 nM. LI-3948 reduces locomotor activity and grooming behavior in mice and induces hypothermia. LI-3948 is a moderate P-glycoprotein efflux substrate, with low clearance in rodents and high plasma protein binding. LI-3948 can be used for central nervous system-related research. | ||||||||||||||||||||
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