3025448-71-6
Chemical Structure
XY-09-36
- CAS No.: 3025448-71-6
- Formula:C48H58FN7O8S
- Molecular Weight:912.08
InChIKey: GNFWHPXWDLWPQG-QLMCDVMBSA-N
SMILES: ONC(C1=CC2=C(C=CN2CCOC3=CC=C(CN(C)CCCOC4=CC(C5=C(C)N=CS5)=CC=C4CNC([C@H]6N(C([C@H](C(C)(C)C)NC(C7(F)CC7)=O)=O)C[C@H](O)C6)=O)C=C3)C=C1)=O
Biological Activity: XY-09-36 is a HDAC8 PROTAC degrader with a DC50 value of 30 nM (HEK 293T eGFP.HDAC8-IRES-mCherry reporter cells, 24 h). XY-09-36 binds HDAC8 and recruits VHL E3 ubiquitin ligase, inducing HDAC8 ubiquitination and proteasomal degradation; the IC50 values of XY-09-36 against HDAC8 and HDAC6 are 2.03 μM and 7.21 μM, respectively. XY-09-36 selectively reduces the viability of STAG2-mutant Ewing sarcoma cells. XY-09-36 increases acetylated SMC3 levels. XY-09-36 can be used for research on Ewing sarcoma[1].
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XY-09-36 | XY-09-36 is a HDAC8 PROTAC degrader with a DC50 value of 30 nM (HEK 293T eGFP.HDAC8-IRES-mCherry reporter cells, 24 h). XY-09-36 binds HDAC8 and recruits VHL E3 ubiquitin ligase, inducing HDAC8 ubiquitination and proteasomal degradation; the IC50 values of XY-09-36 against HDAC8 and HDAC6 are 2.03 μM and 7.21 μM, respectively. XY-09-36 selectively reduces the viability of STAG2-mutant Ewing sarcoma cells. XY-09-36 increases acetylated SMC3 levels. XY-09-36 can be used for research on Ewing sarcoma. | |||||||||||||||||||||
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