3025799-28-1
3025799-28-1
Chemical Structure
FGFR2/3-IN-2
- CAS No.: 3025799-28-1
- Formula:C29H23FN6O3
- Molecular Weight:522.53
SMILES: CC1=NC(OC2=CC=C(C=C2)C3=C(N4C(C=NC(C)=C4)=C3C(N)=O)C5=CC=C(C=C5)NC(C(F)=C)=O)=NC=C1
Biological Activity: FGFR2/3-IN-2 (compound 10) is an orally active FGFR2 and FGFR3 inhibitor. FGFR2/3-IN-2 inhibits FGFR2 and FGFR3 with IC50s of 3.7 nM and 31.2 nM (preincubation time 1 h), respectively. FGFR2/3-IN-2 spares FGFR1/4 and other kinases without causing diarrhea and serum phosphate elevation in vivo. FGFR2/3-IN-2 induces tumor stasis or regression in the SNU-16 gastric cancer model[1].
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FGFR2/3-IN-2 | FGFR2/3-IN-2 (compound 10) is an orally active FGFR2 and FGFR3 inhibitor. FGFR2/3-IN-2 inhibits FGFR2 and FGFR3 with IC50s of 3.7 nM and 31.2 nM (preincubation time 1 h), respectively. FGFR2/3-IN-2 spares FGFR1/4 and other kinases without causing diarrhea and serum phosphate elevation in vivo. FGFR2/3-IN-2 induces tumor stasis or regression in the SNU-16 gastric cancer model. | |||||||||||||||||||||
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