3025799-76-9
Chemical Structure
ISM7594
- CAS No.: 3025799-76-9
- Formula:C29H22F2N6O3
- Molecular Weight:540.52
InChIKey: VIZRMHXRFKBYOW-UHFFFAOYSA-N
SMILES: C=C(C(NC1=CC=C(C=C1)C2=C(C3=CC=C(C(F)=C3)OC4=NC=CC(C)=N4)C(C(N)=O)=C5C=C(C=NN52)C)=O)F
Biological Activity: ISM7594 is an orally active FGFR2/3 inhibitor. ISM7594 shows broad-spectrum antiproliferative potency in FGFR2- or FGFR3-altered cancer cell panels, including FGFR2/3 amplification, fusion, and mutation (BaF3-TEL-FGFR2-V564F (IC50 = 0.067 nM), BaF3-TEL-FGFR2-V564I (IC50 = 2 nM)) types. ISM7594 inhibits tumor growth in a dose-dependent manner. ISM7594 can be used for the study of advanced solid tumors with FGFR2/3 aberrations[1].
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ISM7594 | ISM7594 is an orally active FGFR2/3 inhibitor. ISM7594 shows broad-spectrum antiproliferative potency in FGFR2- or FGFR3-altered cancer cell panels, including FGFR2/3 amplification, fusion, and mutation (BaF3-TEL-FGFR2-V564F (IC50 = 0.067 nM), BaF3-TEL-FGFR2-V564I (IC50 = 2 nM)) types. ISM7594 inhibits tumor growth in a dose-dependent manner. ISM7594 can be used for the study of advanced solid tumors with FGFR2/3 aberrations. | |||||||||||||||||||||
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