3025838-18-7
Chemical Structure
PRMT5-MTA-IN-4
- CAS No.: 3025838-18-7
- Formula:C26H22ClFN6O2
- Molecular Weight:504.94
InChIKey: FZDBDHNJIZVGMP-UHFFFAOYSA-N
SMILES: NCC1=NNC(C2=C(C=C)C=C(C3=[C@]([C@]4=C(C#N)C(OC5(C)CC5)=CC(Cl)=C4F)N(C)N=C3)C=C21)=O
Biological Activity: PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50=8 nM). PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines (e.g., IC50=0.3 μM in DLD-1 cells). PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma[1].
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PRMT5-MTA-IN-4 | PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50=8 nM). PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines (e.g., IC50=0.3 μM in DLD-1 cells). PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma. | |||||||||||||||||||||
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