3025841-47-5
3025841-47-5
Chemical Structure
FXR agonist 4
- CAS No.: 3025841-47-5
- Formula:C21H28ClN3O
- Molecular Weight:373.92
IUPAC Name: ((3r,5r,7r)-adamantan-1-yl)(4-(2-amino-5-chlorophenyl)piperazin-1-yl)methanone
InChIKey: SNWNZTLWPJKTEO-MSMDPAEMSA-N
SMILES: ClC1=CC(N2CCN(C(C34C[C@@H]5C[C@H](C4)C[C@@H](C5)C3)=O)CC2)=C(N)C=C1
Biological Activity: FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD)[1].
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FXR agonist 4 | 99.37% | FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD). | ||||||||||||||||||||
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