3026543-19-8
3026543-19-8
Chemical Structure
RIPK1-IN-20
- CAS No.: 3026543-19-8
- Formula:C28H26F3N5O4
- Molecular Weight:553.53
InChIKey: KFHZLTRBSZRXEH-UHFFFAOYSA-N
SMILES: O=C(N1CCC2=CC(C3=CN(CC4(COC4)C)C5=C3C(N)=NNC5=O)=CC=C21)CC6=CC(OC(F)(F)F)=CC=C6
Biological Activity: RIPK1-IN-20 (compound 13c) has a favorable RIPK1 kinase inhibition activity with an IC50 value of 59.8 nM. RIPK1-IN-20 blocks TNFα-induced necroptosis in both human and murine cells (EC50=1.06–4.58 nM)[1].
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RIPK1-IN-20 | RIPK1-IN-20 (compound 13c) has a favorable RIPK1 kinase inhibition activity with an IC50 value of 59.8 nM. RIPK1-IN-20 blocks TNFα-induced necroptosis in both human and murine cells (EC50=1.06–4.58 nM). | |||||||||||||||||||||
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