3027045-35-5
3027045-35-5
Chemical Structure
PPARα/γ agonist 3
- CAS No.: 3027045-35-5
- Formula:C27H26FN3O2S
- Molecular Weight:475.58
InChIKey: XZZBEVKWMQCPFH-MUFRIFMGSA-N
SMILES: FC1=CC=C(COC2=CC(CCC(C)(CC/C=N/NC3=NC4=C(C=CC=C4)S3)O5)=C5C=C2)C=C1
Biological Activity: PPARα/γ agonist 3 (Compound 4) is a dual agonist of PPARα/γ. PPARα/γ agonist 3 has anti-inflammatory activity, significantly reducing inflammatory markers such as IL-6 and MCP-1 on THP-1 macrophages through NF-κB activation. PPARα/γ agonist 3 can be used in the study of metabolic syndrome and metabolic dysfunction-related fatty liver disease (MAFLD)[1].
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PPARα/γ agonist 3 | PPARα/γ agonist 3 (Compound 4) is a dual agonist of PPARα/γ. PPARα/γ agonist 3 has anti-inflammatory activity, significantly reducing inflammatory markers such as IL-6 and MCP-1 on THP-1 macrophages through NF-κB activation. PPARα/γ agonist 3 can be used in the study of metabolic syndrome and metabolic dysfunction-related fatty liver disease (MAFLD). | |||||||||||||||||||||
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