3027548-08-6
3027548-08-6
Chemical Structure
BCL-xL ligand 4
- CAS No.: 3027548-08-6
- Formula:C47H56ClF3N6O6S3
- Molecular Weight:989.63
InChIKey: XIJAYVOVOVTAOZ-OIZGGULRSA-N
SMILES: ClC1=CC=C(C=C1)C2=C(C[C@](CN)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(C=C5)N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(=O)=O)=O
Biological Activity: BCL-xL ligand 4 is a BCL-xL ligand that can be used for the synthesis of PROTACs, such as PZ703b (HY-115718), PZ703b TFA (HY-115718A), and PZ703b hydrochloride (HY-115718B)[1][2].
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BCL-xL ligand 4 | BCL-xL ligand 4 is a BCL-xL ligand that can be used for the synthesis of PROTACs, such as PZ703b (HY-115718), PZ703b TFA (HY-115718A), and PZ703b hydrochloride (HY-115718B). | |||||||||||||||||||||
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References
- [1]. Yi Xu, et al. Mivebresib synergized with PZ703b, a novel Bcl-xl PROTAC degrader, induces apoptosis in bladder cancer cells via the mitochondrial pathway. Biochem Biophys Res Commun. 2022 Oct 1;623:120-126. [Content Brief]
- [2]. Pratik Pal, et al. Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition. J Med Chem. 2021 Oct 14;64(19):14230-14246. [Content Brief]
