3027931-27-4
Chemical Structure
PBA-Q76-O16B
- CAS No.: 3027931-27-4
- Formula:C47H86BN2O6S4+
- Molecular Weight:914.27
InChIKey: BAICJFONGVTVJV-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCSSCCOC(CC[N+](CCN1CCCC1)(CC2=CC=C(B(O)O)C=C2)CCC(OCCSSCCCCCCCCCCCC)=O)=O
Biological Activity: PBA-Q76-O16B is a lipid that cannot cross the blood-brain barrier on its own, but can mediate cargo delivery into the brains of mice when blended with NT1 lipids. After forming stable small-sized lipid nanoparticles with NT1-O12B, PBA-Q76-O16B delivers drugs into the brains of mice. When formulated into lipid nanoparticles with NT1-O14B, PBA-Q76-O16B delivers (-27) GFP-Cre recombinase into mouse brain cells, driving functional gene recombination in multiple brain regions. PBA-Q76-O16B can be used in studies related to lipid nanoparticles (LNPs)[1][2].
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PBA-Q76-O16B | PBA-Q76-O16B is a lipid that cannot cross the blood-brain barrier on its own, but can mediate cargo delivery into the brains of mice when blended with NT1 lipids. After forming stable small-sized lipid nanoparticles with NT1-O12B, PBA-Q76-O16B delivers drugs into the brains of mice. When formulated into lipid nanoparticles with NT1-O14B, PBA-Q76-O16B delivers (-27) GFP-Cre recombinase into mouse brain cells, driving functional gene recombination in multiple brain regions. PBA-Q76-O16B can be used in studies related to lipid nanoparticles (LNPs). | |||||||||||||||||||||
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References
- [1]. Ma F, et al.. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Science Advances. 2020;6:eabb4429.
- [2]. Ji W, et al.. SSK1-Loaded Neurotransmitter-Derived Nanoparticles for Alzheimer's Disease Therapy via Clearance of Senescent Cells. Small (Weinheim an der Bergstrasse, Germany). 2024 Jun;20(26):e2308574. [Content Brief]
