3029365-95-2
3029365-95-2
Chemical Structure
BCL-xL ligand 6
- CAS No.: 3029365-95-2
- Formula:C32H29IN4O4S2
- Molecular Weight:724.63
IUPAC Name: ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-iodophenoxy)propyl)thiazole-4-carboxylate
InChIKey: NOZZAZZDPDCLQI-UHFFFAOYSA-N
SMILES: O=C(C1=C(CCCOC2=CC=C(I)C=C2)SC(N3CCC4=C(C(C(NC5=NC6=CC=CC=C6S5)=O)=CC=C4)C3)=N1)OCC
Biological Activity: BCL-xL ligand 6 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BCL-xL ligand 6 | 99.06% | BCL-xL ligand 6 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Bcl-xL antagonist 2 | 98.86% | Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
BCL-XL-IN-4 | BCL-XL-IN-4 (compound 10) is a potent and selective BCL-XL inhibitor with Ki values of 0.042, 170 nM for BCL-XL, BCL-2, respectively. BCL-XL-IN-4 shows cytotoxicity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
PROTAC Bcl-xL degrader-2 | 98.23% | PROTAC Bcl-xL degrader-2 is a selective Bcl-xL PROTAC degrader with a DC50 of 4.8 nM against Bcl-xL. PROTAC Bcl-xL degrader-2 forms a ternary complex with VHL E3 ligase, thereby redirecting the ubiquitin-proteasome system to mediate the degradation of Bcl-xL. PROTAC Bcl-xL degrader-2 triggers Apoptosis. PROTAC Bcl-xL degrader-2 can be used in the research of solid tumors and hematologic malignancies. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
WEHI-539 | WEHI-539 is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
WEHI-539 hydrochloride | 99.72% | WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
BCL-XL-IN-3 | BCL-XL-IN-3 is a cell-impermeable BCL-XL inhibitor with a Ki of 16 pM. BCL-XL-IN-3 disrupts the critical hydrogen bond network via methylation of the nitrogen atom on the P2-binding amide bond, resulting in complete loss of cellular activity against BCL-XL. BCL-XL-IN-3 can be used in non-small cell lung cancer and cancer-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
BCL-xL ligand 5 | BCL-xL ligand 5 is a Bcl-xL ligand with an IC50 of 0.5 nM. BCL-xL ligand 5 can be used for the synthesis of PROTACs, such as PROTAC Bcl-xL degrader-2 (HY-139309). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
A-1155463 | 98.02% | A-1155463, a chemical probe, is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell. A-1155463 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
A-1331852 | 99.93% | A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sirtuin modulator 1 | 99.85% | Sirtuin modulator 1 is a modulator of SIRTl, a homolog of SIRT3, with EC1.5 of < 1 μM, extracted from patent WO 2010071853 A1, Compound No.4. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
