3029827-91-3
3029827-91-3
Chemical Structure
Glucosylceramide synthase-IN-3
- CAS No.: 3029827-91-3
- Formula:C21H20FN3O3
- Molecular Weight:381.40
IUPAC Name: (R)-quinuclidin-3-yl (2-(4-fluorophenyl)benzo[d]oxazol-4-yl)carbamate
InChIKey: MLVNGCMNEYHLOF-SFHVURJKSA-N
SMILES: O=C(O[C@H]1CN2CCC1CC2)NC3=CC=CC4=C3N=C(O4)C5=CC=C(C=C5)F
Biological Activity: Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research[1][2].
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Glucosylceramide synthase-IN-3 | 99.11% | Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research. | ||||||||||||||||||||
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References
- [1]. Mali Cosden, et al. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiol Dis. 2021 Nov;159:105507. [Content Brief]
- [2]. Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290 [Content Brief]
