303059-39-4
Chemical Structure
IGGi-11
- CAS No.: 303059-39-4
- Formula:C23H28N2O8S2
- Molecular Weight:524.60
IUPAC Name: 4,4'-((9H-fluorene-2,7-disulfonyl)bis(methylazanediyl))dibutyric acid
InChIKey: OVLVWTBOQLHECZ-UHFFFAOYSA-N
SMILES: O=C(O)CCCN(C)S(=O)(=O)C1=CC=C2C=3C=CC(=CC3CC2=C1)S(=O)(=O)N(C)CCCC(=O)O
Biological Activity: IGGi-11 is a competitive Gαi inhibitor with a Kd of 5.3 μM for sGαi3. IGGi-11 binds to the GIV interaction region of Gαi3, blocks non-canonical G protein signaling, and does not interfere with Gαi nucleotide processing, Gβγ binding, GPCR activation, or effector regulation. IGGi-11 inhibits the pro-invasive properties of metastatic breast cancer. IGGi-11 can be used in related studies on metastatic breast cancer[1][2][3].
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IGGi-11 | IGGi-11 is a competitive Gαi inhibitor with a Kd of 5.3 μM for sGαi3. IGGi-11 binds to the GIV interaction region of Gαi3, blocks non-canonical G protein signaling, and does not interfere with Gαi nucleotide processing, Gβγ binding, GPCR activation, or effector regulation. IGGi-11 inhibits the pro-invasive properties of metastatic breast cancer. IGGi-11 can be used in related studies on metastatic breast cancer. | |||||||||||||||||||||
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References
- [1]. Zhao J, et al. Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression. bioRxiv [Preprint]. 2023 Feb 19:2023.02.18.529092.
- [2]. Ferreras-Gutiérrez M, et al. Integrated NMR-crystallography-computational approach for molecular recognition studies of human Gαi3 protein by a small molecule inhibitor. International journal of biological macromolecules. 2025 Feb;290:138977.
- [3]. Garcia-Marcos M. Heterotrimeric G protein signaling without GPCRs: The Gα-binding-and-activating (GBA) motif. J Biol Chem. 2024 Mar;300(3):105756.
