3030629-73-0
Chemical Structure
TPP-Ce6
- CAS No.: 3030629-73-0
- Formula:C94H90N4O6P33+
- Molecular Weight:1464.66
InChIKey: CTGBPEHOLXWBSE-MEXMCTBWSA-O
SMILES: O=C(C1=C2/C(CC(OCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=C6[C@H]([C@@H](C(/C=C7N/C(C(C=C)=C\7C)=C\C8=N/C(C(CC)=C8C)=C\C(N2)=C1C)=N/6)C)CCC(OCC[P+](C9=CC=CC=C9)(C%10=CC=CC=C%10)C%11=CC=CC=C%11)=O)OCC[P+](C%12=CC=CC=C%12)(C%13=CC=CC=C%13)C%14=CC=CC=C%14
Biological Activity: TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma[1][2][3][4][5][6].
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TPP-Ce6 | TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma. | |||||||||||||||||||||
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References
- [1]. Luo Y, et al. Carrier-free Nanotherapeutics unleashed: Ce6/siPD-L1 co-delivery system synergizes photodynamic and RNAi therapies to combat breast cancer. Int J Biol Macromol. 2025;318(Pt 1):144962. [Content Brief]
- [2]. Nguyen Cao TG, et al. Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier. Acta Pharm Sin B. 2023;13(9):3834-3848. [Content Brief]
- [3]. Chen Y, et al. Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming. J Nanobiotechnology. 2024;22(1):801. Published 2024 Dec 28. [Content Brief]
- [4]. Nguyen Cao TG, et al. Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy. J Control Release. 2023;354:651-663. [Content Brief]
- [5]. Ali MS, et al. Triphenylphosphine-Based Mitochondrial Targeting Nanocarriers: Advancing Cancer Therapy. Clin Pharmacol. 2025;17:119-141. Published 2025 Jun 10. [Content Brief]
- [6]. Quan Z, et al. ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine. Small. 2025;21(5):e2410031. [Content Brief]
