3031411-05-6
Chemical Structure
HDAC-IN-48
- CAS No.: 3031411-05-6
- Formula:C13H17N3O3S
- Molecular Weight:295.36
IUPAC Name: 2-ethynyl-N-(7-(hydroxyamino)-7-oxoheptyl)thiazole-4-carboxamide
InChIKey: XRBINVLWFQEUIS-UHFFFAOYSA-N
SMILES: O=C(C1=CSC(C#C)=N1)NCCCCCCC(NO)=O
Biological Activity: HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI50~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins[1]. HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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HDAC-IN-48 | HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI50~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins. HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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