3031418-84-2
3031418-84-2
Chemical Structure
Topo I/COX-2-IN-1
- CAS No.: 3031418-84-2
- Formula:C21H18ClFN2O3
- Molecular Weight:400.83
IUPAC Name: 2-((3-chloro-2-methylphenyl)amino)-N-(3,4-dihydroxybenzyl)-5-fluorobenzamide
InChIKey: MADVKIJUDVHXOT-UHFFFAOYSA-N
SMILES: CC1=C(C=CC=C1NC2=CC=C(C=C2C(NCC3=CC=C(C(O)=C3)O)=O)F)Cl
Biological Activity: Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC50 value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity[1].
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Topo I/COX-2-IN-1 | Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC50 value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity. | |||||||||||||||||||||
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