3031485-19-2
Chemical Structure
Autophagy-IN-1
- CAS No.: 3031485-19-2
- Formula:C23H25NO7
- Molecular Weight:427.45
IUPAC Name: tert-butyl ((3aS,8bR,E)-3-((((R)-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)oxy)methylene)-2-oxo-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-7-yl)carbamate
InChIKey: RGNNYAWPIKPOLQ-PVBZKGQNSA-N
SMILES: O=C1O[C@@H](O/C=C([C@@H]2CC3=CC=C4NC(OC(C)(C)C)=O)/C(O[C@H]2C3=C4)=O)C(C)=C1C
Biological Activity: Autophagy-IN-1 is a potent autophagy/mitophagy inhibitor, acts by selectively increasing the autophagic flux while blocking the autophagosome-lysosome fusion in cancer cells. Autophagy-IN-1 can induce apoptosis and cell cycle arrest. Autophagy-IN-1 significantly inhibits tumor growth in an HCT116 xenograft mouse model and with low toxicity. Autophagy-IN-1 can be used for researching colorectal cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Autophagy-IN-1 | 99.18% | Autophagy-IN-1 is a potent autophagy/mitophagy inhibitor, acts by selectively increasing the autophagic flux while blocking the autophagosome-lysosome fusion in cancer cells. Autophagy-IN-1 can induce apoptosis and cell cycle arrest. Autophagy-IN-1 significantly inhibits tumor growth in an HCT116 xenograft mouse model and with low toxicity. Autophagy-IN-1 can be used for researching colorectal cancer. | ||||||||||||||||||||
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