3031505-76-4
3031505-76-4
Chemical Structure
Aurora A/PKC-IN-1
- CAS No.: 3031505-76-4
- Formula:C16H14N6OSe2
- Molecular Weight:464.24
IUPAC Name: 3-fluoro-2-methyl-5-nitrobenzenesulfonyl chloride
InChIKey: JKTIMGKTTJTCFS-VIFPVBQESA-N
SMILES: O=C1N(C2=NC(N[C@@H]3C[Se]CC3)=C4N=CNC4=N2)[Se]C5=C1C=CC=C5
Biological Activity: Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].
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Aurora A/PKC-IN-1 | Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity. | |||||||||||||||||||||
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