3031514-69-6
Chemical Structure
PROTAC LRRK2 Degrader-1
- CAS No.: 3031514-69-6
- Formula:C45H54FN9O5
- Molecular Weight:819.98
IUPAC Name: 3-(4-fluoro-7-methyl-5-(4-(((1r,4r)-4-((4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)piperazin-1-yl)methyl)cyclohexyl)oxy)piperidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: MMPCWXISESNYDH-ARBFJVLTSA-N
SMILES: O=C1C=2C(CN1C3C(=O)NC(=O)CC3)=C(F)C(=CC2C)N4CCC(O[C@H]5CC[C@H](CN6CCN(CC6)C=7C=C(N=CN7)C=8C=9C(NN8)=CC=C(OC%10(C)CC%10)C9)CC5)CC4
Biological Activity: PROTAC LRRK2 Degrader-1 (compound 18) is a leucine-rich repeat kinase 2 (LRRK2) PROTAC degrader with an IC50 value less than 10 nM. PROTAC LRRK2 Degrader-1 can be used in the research of Parkinson's disease[1].
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PROTAC LRRK2 Degrader-1 | PROTAC LRRK2 Degrader-1 (compound 18) is a leucine-rich repeat kinase 2 (LRRK2) PROTAC degrader with an IC50 value less than 10 nM. PROTAC LRRK2 Degrader-1 can be used in the research of Parkinson's disease. | |||||||||||||||||||||
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