3031837-35-8
Chemical Structure
JAK-IN-23
- CAS No.: 3031837-35-8
- Formula:C23H22Cl2N4O
- Molecular Weight:441.35
IUPAC Name: 2,6-dichloro-4-(2-methyl-1-(1-methylpiperidin-4-yl)-1H-imidazo[4,5-c]quinolin-8-yl)phenol
InChIKey: JEESDVDVWGRNFE-UHFFFAOYSA-N
SMILES: OC1=C(Cl)C=C(C2=CC=C3N=CC(N=C(C)N4C5CCN(C)CC5)=C4C3=C2)C=C1Cl
Biological Activity: JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JAK-IN-23 | 98.88% | JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD). | ||||||||||||||||||||
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