3032400-33-9
Chemical Structure
Glutaminyl cyclases-IN-1
Synonym(s): IsoQC-IN-1
- CAS No.: 3032400-33-9
- Formula:C25H30N6O2S
- Molecular Weight:478.61
IUPAC Name: 5-(1-(3-methoxy-4-(3-(piperidin-1-yl)propoxy)benzyl)-1H-benzo[d]imidazol-5-yl)-1,3,4-thiadiazol-2-amine
InChIKey: VXNMURILOSNNJI-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(CN2C=NC3=CC(C4=NN=C(S4)N)=CC=C32)=C1)OCCCN5CCCCC5
Biological Activity: Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glutaminyl cyclases-IN-1 | 98.21% | Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages. | ||||||||||||||||||||
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