3032432-71-3
Chemical Structure
S1g-10
- CAS No.: 3032432-71-3
- Formula:C26H31N3OS
- Molecular Weight:433.61
InChIKey: CFZOZLLGYXBIOC-UHFFFAOYSA-N
SMILES: O=C1C(C#N)=C(C2=CC=C(C3=C2C1=CC=C3)SC4CCCCC4)NCCN(CC)CC
Biological Activity: S1g-10 is an Hsp70-Bim protein-protein interaction inhibitor and an Hsp70 ATPase inhibitor. S1g-10 binds the Hsp70 nucleotide-binding domain at the Bim interface, inhibits Bim-stimulated ATPase activity, and selectively disrupts Hsp70-Bim without affecting Hsp70-Bag3, thereby inhibiting mitophagy (Autophagy), inducing apoptosis (Apoptosis), and reducing the survival and self-renewal of CML leukemia stem cells. S1g-10 can be used for research on chronic myeloid leukemia and breast cancer[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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S1g-10 | 99.08% | S1g-10 is an Hsp70-Bim protein-protein interaction inhibitor and an Hsp70 ATPase inhibitor. S1g-10 binds the Hsp70 nucleotide-binding domain at the Bim interface, inhibits Bim-stimulated ATPase activity, and selectively disrupts Hsp70-Bim without affecting Hsp70-Bag3, thereby inhibiting mitophagy (Autophagy), inducing apoptosis (Apoptosis), and reducing the survival and self-renewal of CML leukemia stem cells. S1g-10 can be used for research on chronic myeloid leukemia and breast cancer. | ||||||||||||||||||||
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References
- [1]. Song T, et al. Hsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells. Stem cell reports. 2026 Jan 13;21(1):102751.
- [2]. Wang Z, et al. Exploiting the "Hot-Spots" of Hsp70Bim ProteinProtein Interaction to Optimize the 1-Oxo-1-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70Bim Inhibitors. Journal of medicinal chemistry. 2023 Dec 14;66(23):16377-16387. [Content Brief]
- [3]. Jiang M, et al. Revealing GRP75-Mediated Mitochondrial Stability That Promotes Breast Cancer Survival through Subcellular Anchoring of 70 kDa Heat Shock Protein Inhibitors. Journal of medicinal chemistry. 2025 Sep 25;68(18):19169-19183. [Content Brief]
- [4]. Jiang M, et al. Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein-Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy. Journal of medicinal chemistry. 2024 Jul 25;67(14):12068-12084. [Content Brief]
- [5]. Wang Z, et al. Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of Intracellular and Extracellular Proteins. Journal of medicinal chemistry. 2026 Apr 09;69(7):8417-8432. [Content Brief]
- [6]. Zhang H, et al. A kinase-independent Bcr-Abl function mediating an Hsp70-Bim protein-protein interaction in chronic myeloid leukemia. International journal of biological macromolecules. 2025 May;310(Pt 3):143249. [Content Brief]
