3032439-98-5
3032439-98-5
Chemical Structure
PITCOIN4
- CAS No.: 3032439-98-5
- Formula:C30H29N7O3S2
- Molecular Weight:599.73
InChIKey: WBXQHPRLMAYBJC-UHFFFAOYSA-N
SMILES: CC(C)(NC(CC1=CSC(NC(CSC(N2CCC3=CC=CC=C3)=NC4=C(C2=O)N=CC=N4)=O)=N1)=O)C5=CC=CC=C5
Biological Activity: PITCOIN4 is a selective PI3K-C2α inhibitor with an IC50 value of 56 nM. PITCOIN4 does not affect PI (3,4) P2 accumulation or ROS production[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PITCOIN4 | 99.97% | PITCOIN4 is a selective PI3K-C2α inhibitor with an IC50 value of 56 nM. PITCOIN4 does not affect PI (3,4) P2 accumulation or ROS production. | ||||||||||||||||||||
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References
- [1]. Kücükdisli M, et al. Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition. Journal of medicinal chemistry. 2023 Oct 26;66(20):14278-14302. [Content Brief]
- [2]. Moussaoui S, et al. 3′ Plasma Membrane Phosphoinositides Sustain ROS Production at Persistent Non-canonical Phagocytic Cups that Promote Macrophage Control of Aspergillus fumigatus Hyphae. bioRxiv. 2026:2026-09.
