3032446-61-7
3032446-61-7
Chemical Structure
PDK-IN-2
- CAS No.: 3032446-61-7
- Formula:C17H23AsCl2N2O2S2
- Molecular Weight:497.33
InChIKey: PXXYVYATHKCHQK-UHFFFAOYSA-N
SMILES: ClC(C(NCCCCCC(NC1=CC=C(C=C1)[As]2SCCCS2)=O)=O)Cl
Biological Activity: PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM). PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model[1].
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PDK-IN-2 | PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM). PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model. | |||||||||||||||||||||
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